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Monooxygenases act by sequentially transferring two electrons from NADH or NADPH to one of the two atoms of oxygen in O 2 , generating H 2 O from one oxygen atom and incorporating the other oxygen atom into an organic compound as a hydroxyl group (R-OH)

Since the cytoplasmic vacuolation may mimic microvesicular fatty change, a descriptive diagnosis of cytoplasmic vacuolation is recommended in the absence of electron microscopy or special immunostaining

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Strategies to increase half-life To design GLP-RAs with an increased circulation time, a broad array of half-life extension strategies has been utilized including sequential modification (Byetta and Adlyxin), attachment of a fatty-acid (Victoza and Ozempic), development of a polymer-based sustained release formulation (Bydureon), fusion with human serum albumin (Tanzeum), and fusion with the fragment crystallizable (Fc) region of a monoclonal antibody (Trulicity) (Figure 1)

I 1817 Discovery Berzelius Sweden Selenium was discovered in 1817 by the Swedish chemist Jns Jacob Berzelius one of the founding figures of modern analytical chemistry